Fury is investigating a series of agents who have gone berserk, and tracks the problem down to its source. Someone has been injecting them with a fatal hallucinogen, and Fury gets a dose himself. He's too far gone to recognize Jimmy Woo, Dum Dum Dugan or Gabe Jones when he meets them, and cannot be tracked as his locator was destroyed. Can S.H.I.E.L.D. find and cure its director in time to stop the conspiracy and save his life?