Viper, formerly Madame Hydra has infiltrated the S.H.I.E.L.D. helicarrier, and has all of the agents stationed aboard under her hypnotic control. She intends to use the floating base in an attack on the capital building as President Carter addresses Congress. Aboard the carrier, Nick Fury, Spider-Man and Shang-Chi fight a desperate battle to prevent this assassination from taking place. Aiding them is the Black Widow, who has fallen into a 'safe' persona of Nancy Rushman, an elementary school teacher, after her torture at Viper's hands. Can she remember who she truly is in time to help her comrades in arms save the President?